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dc.contributor.authorDrabe, Nickson
dc.contributor.authorMusudo, Enoch
dc.date.accessioned2021-08-19T11:07:27Z
dc.date.available2021-08-19T11:07:27Z
dc.date.issued2020-12
dc.identifier.urihttp://hdl.handle.net/20.500.12281/10882
dc.descriptionA research report submitted to the department of pharmacy in partial fulfillment of the requirement for the award of a bachelor of pharmacy degree of Makerere Universityen_US
dc.description.abstractABSTRACT Diabetes Mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia. It causes significant physiological aberrations that eventually lead to chronic complications that are responsible for most of the mortalities and morbidities typical of the disease. Study objectives: The general objective was to evaluate the combined anti-diabetic effect of a methanolic extract of Solanum indicum fruit and metformin in alloxan – induced diabetic albino rat. The specific objective was to determine the anti-diabetic effect of the combination of a methanolic extract of Solanum indicum fruits and metformin. Methods: The study was a controlled experimental study. Diabetes was induced using 150mg/Kg via intra-peritoneal route. FBG levels were determined using a Code free glucometer and chronic diabetes was confirmed for all animals whose FBG is greater than 8.33mmol/L. Chronic diabetic animals were fasted overnight and all groups were treated as follows group I (distilled water 0.2mL) groups II (Metformin 50 mg/Kg), III (SIE 100mg/Kg), IV (Metformin: SIE 1:1), V (Metformin: SIE 1:2) and VI (Metformin: SIE 2:1). FBG levels were determined at regular intervals of 3 days. Study findings: The percentage yield of the extract was 2.43% w/w. There was no significant difference in the reduction of FBG levels amongst groups II, III, IV, V and VI (P> 0.05). Group III (SIE 100mg/Kg) showed the highest percentage (83%) reduction over the study 12-day study period. Conclusions: Solanum indicum fruit extracts (SIE) exhibits a comparable hypoglycemic effect to metformin. However, the combination of Metformin and SIE is not superior to either preparation administered singly. Recommendations: Future studies need to embark on the isolation and characterization of the saponins that are responsible for the hypoglycemic effects. Also there is a need to elucidate the actual mechanism of action by which the saponins exhibit the hypoglycemiceffen_US
dc.language.isoenen_US
dc.publisherMakerere Universityen_US
dc.subjectSolanum indicumen_US
dc.subjectMethanolic extracten_US
dc.subjectAnti-diabetic effecten_US
dc.subjectMetforminen_US
dc.titleEvaluation of the combined anti-diabetic effect of a methanolic extract of solanum indicum fruit and metformin in alloxan - induced diabetic albino ratsen_US
dc.typeThesisen_US


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