Therapeutic evaluation of administration of autogenous vaccine along with immune-modulators in treatment of Bovine papillomatosis-case study

Abstract

Cutaneous bovine papillomatosis is a benign proliferative neoplasm caused by papilloma virus. Cutaneous papillomas usually appear as multiple, sessile or pedunculated, circumscribed grey-white to dark brown black outgrowth and may appear on skin over different body parts. Although the papillomas usually regress spontaneously, they occasionally can persist and progress to squamous cell carcinoma, metabolism disorders, difficulty in milking and suckling especially when lesions are on the teats, snapping-off causing secondary infections, eating disturbances, aesthetic and animal welfare concerns. Several treatment options like antimony preparations, homeopathic drugs, autogenous vaccines, and Ivermectins have been tried with varying degree of success. In this study, the approach involving administration of autogenous bovine papillomatosis vaccine along with immuno-modulators was evaluated for its therapeutic benefit in management of bovine papillomas from a selected farm in Kiboga district. Seven animals between ages of 8-to 15 months, bearing papilloma lesions were studied. Lesions were resected and an autogenous vaccine prepared from them. 50 ml of the vaccine from each of the resected tissues. 10-15 ml of the vaccine was injected weekly for four weeks including injection of immune-modulators at the first week of administration. The lesions regressed within five weeks and better regression was seen with those which were mildly and moderately affected. These results confirms that administration of autogenous vaccine along with immune-modulators could hasten recovery of the animals from bovine papillomatosis.