Histopathological profile of breast cancer among women at Uganda Cancer Institute, Mulago Referral Hospital in Kampala Uganda

Abstract

Currently breast cancer still remains the most commonly diagnosed female cancer globally with a significant geographic, racial and ethnical variations in its incidence. This research examined the frequency and histological types and staging of Breast Cancer in Uganda Cancer Institute, Mulago referral Hospital in Kampala. Records of H and E stained slides of breast biopsies diagnosed at UCI from 2017 to 2020 were archived and studied. Request forms were scrutinized for clinical bio data, diagnosis and histological sections were analyzed. Data obtained were analyzed using Excel and Statistical Package for the Social Sciences (SPSS) and value presented descriptively. During this period, 418 breast lesions were seen. Out of this, 247 were Breast Cancers. The peak age incidence for Breast Cancer and its variants was 40 49 years accounting for 37% (n = 92/247). The mean age of Breast Cancer was 46 years. Invasive carcinoma of no special type (NST) was the most encountered histological group of breast carcinoma constituting 77.7% (n = 192/247) with the high grade invasive ductal carcinoma as the leading diagnosis. Majority of patients presented with Stages III and IV.