Evaluation of Gastric Anti-ulcer activity and acute toxicity of ethanolic leaf extracts of Plectranthus caespitosus Lukhoba & A.J. Paton in winstar albino rats.

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dc.contributor.author Owamukama, Sheillah
dc.date.accessioned 2023-11-17T12:59:27Z
dc.date.available 2023-11-17T12:59:27Z
dc.date.issued 2023-08-04
dc.description a research report submitted to the Department of Plant Sciences, Microbiology And Biotechnology, College of Natural Sciences, in partial fulfillment of the requirements for the award of the Degree Of Bachelor of Science In Biotechnology of Makerere University en_US
dc.description.abstract Plectranthus caespitosus is a plant used in traditional medicine for the treatment of various ailments, including gastric ulcers. The aim of this study was to assess the phytochemistry, acute toxicity, and anti-ulcer activity of the ethanolic leaf extract of P. caespitosus in Winstar albino rats. The phytochemical analysis revealed the presence of saponins, alkaloids, flavonoids, tannins, and phenolic compounds in the extract. The acute toxicity test showed that the extract was safe up to doses above 5000 mg/kg, with no adverse effects on the skin or body weight of the animals. The anti-ulcer activity was evaluated using the ethanol-induced ulcer model. The extract showed a significant reduction in ulcer scores compared to the negative control group. The results suggest that P. caespitosus has potential anti-ulcer properties, which may be attributed to its phytochemical constituents and their synergistic effects. en_US
dc.identifier.citation Owamukama, S. (2023). Evaluation of Gastric Anti-ulcer activity and acute toxicity of ethanolic leaf extracts of Plectranthus caespitosus Lukhoba & A.J. Paton in winstar albino rats. (Unpublished Resesarch Report). (Mak UD). Makerere University, Kampala, Uganda. en_US
dc.identifier.uri http://hdl.handle.net/20.500.12281/17099
dc.language.iso en en_US
dc.publisher Makerere University en_US
dc.subject Gastric Anti-ulcer activity en_US
dc.subject winstar albino rats en_US
dc.subject Plectranthus caespitosus ethanolic extracts en_US
dc.subject Plectranthus caespitosus phytochemistry en_US
dc.subject Plectranthus caespitosus acute toxicity en_US
dc.subject Plectranthus caespitosus Lukhoba en_US
dc.title Evaluation of Gastric Anti-ulcer activity and acute toxicity of ethanolic leaf extracts of Plectranthus caespitosus Lukhoba & A.J. Paton in winstar albino rats. en_US
dc.type Thesis en_US
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