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dc.contributor.authorMusasira, Sarah
dc.date.accessioned2022-06-27T07:43:45Z
dc.date.available2022-06-27T07:43:45Z
dc.date.issued2022-03
dc.identifier.citationMusasira, S. (2022). Determination of the antidiabetic properties of Kombucha (tea fungus) on Wistar Albino rats. (Unpublished undergraduate dissertation). Makerere University, Kampala, Uganda.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12281/13122
dc.descriptionA research report submitted in partial fulfilment of the requirements for the award of Bachelor’s Degree in Biomedical Laboratory Technology of Makerere University Kampalaen_US
dc.description.abstractGlobally, a total of 66.3 million DALYs (disability adjusted life year) and 1.5 million deaths were reported in 2019 alone, as being related to diabetes mellitus. A 2016 survey in Uganda involving 3689 participants found out that majority of the participants identified with hyperglycemia (90.5%) and diabetes 45% were not aware of their hyperglycemic status. The same report showed an increasing incidence in diabetes cases. Current diabetes treatment therapies have been successful, however due to limitations such as high costs, weight loss among. several studies have sought to use animal modules to validate the potential of newly diagnosed antidiabetic agents for future therapies. In the study, the antidiabetic activity of aqueous extract of kombucha which has a long-term claim and history of use by some communities in the treatment of diabetes, was evaluated. the phytochemical constituents of kombucha were also analyzed in this study. Diabetes was induced in albino rats by intraperitoneal injection with 150 mg/kg of Alloxan monohydrate and after 24 hours, the rats were bled from the tip of the tail to measure their blood glucose using glucometer. Rats with blood glucose levels ≥ 150 mg/ dl were considered diabetic and selected for antihyperglycemic study. A total of 24 rats were used for the experiment where by diabetes was induced in 20 of the animals, and 4 rats were left uninduced and labelled group A (Normal control). The other groups were labelled group B (glibenclamide 5mg/kg), C (distilled water) and group E and F as extract treatment groups of concentration 400mg/kg and 800mg/kg respectively. The results showed that Kombucha extract has significant antihyperglycemic activity in the experimental model of diabetes mellitus. The dose of 400mg/kg and 800mg/kg of the extracts significantly reduced the blood glucose levels to 41.82 and 60.4 respectively. The extract also demonstrated high concentration of carbohydrates, flavonoids and phenolics. There were no tannins. This study provided evidence of antidiabetic properties of kombucha which could be as a result of the medicinally important bioactive compounds detected in the tea. However further studies should be done to further validate antidiabetic efficacy and safety of the kombucha.en_US
dc.language.isoenen_US
dc.publisherMakerere Universityen_US
dc.subjectDiabetes mellitusen_US
dc.subjectHyperglycemic statusen_US
dc.subjectHyperglycemiaen_US
dc.subjectDiabetes treatmenten_US
dc.subjectKombucha drinken_US
dc.subjectTea fungusen_US
dc.titleDetermination of the antidiabetic properties of Kombucha (tea fungus) on Wistar Albino ratsen_US
dc.typeThesisen_US


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