| dc.description.abstract | Health care associated infections (HAIs) have been found among the leading causes of morbidity and mortality worldwide (Eyo et al., 2015). P. aeruginosa is an aerobic, motile, a Gram-negative rod which is responsible for 10% of all HAIs and it is among the most common bacterial pathogens with widespread distribution in health care settings despite advances in medical care and introduction of wide variety of antimicrobial agents. This study was done to find resistance profile of P. aeruginosa clinical isolates obtained from archives of microbiology laboratory of Mulago hospital to selected antibiotics and sodium hypochlorite. An experimental study was conducted in which I collected 25 P. aeruginosa clinical isolates from archives of Mulago microbiology laboratory after which all isolates reidentified and reconfirmed by standard protocol. Antibiotic resistance and resistance to the disinfectant of the isolates then tested by Kirby-Bauer disc diffusion method and Agar well diffusion assay respectively. The tests results showed relatively high resistance to ceftazidime (40%), ceftriaxone (28%), piperacillin (24%), and ciprofloxacin (20%),. However 8(32%) of the P. aeruginosa clinical isolates were resistant to more than three drugs. The results showed that 15(60%) of the isolates were resistant to 0.5% sodium hypochlorite solution and 7(28%) of the isolates were resistant to 1.0% sodium hypochlorite solution. Conclusion and Recommendations; P.aeruginosa has started developing resistance against imipenem yet it’s the most recent antipseudomonal drug available for the treatment of severe P. aeruginosa infections, gentamicin, amikacin and ciprofloxacin resistances are also on the rise. Most P. aeruginosa isolates that have developed resistance to antimicrobial drugs have also developed resistance to disinfectant however those isolates that are sensitive to antimicrobial drugs are still sensitive to 1.0% disinfectant though 0.5% disinfectant concentration ineffectiveness in killing P. aeruginosa is on a decline as some of the isolates which were susceptible to antimicrobials were resistant to 0.5% disinfectant thus there is a need for periodical antimicrobial surveillance to check the resistance patterns to antibiotics and disinfectants in both local hospitals and high-level hospitals | en_US |
