An assessment of the determinants of client Pre-Exposure Prophylaxis (PrEP) adherence in Uganda

Abstract

Pre-exposure Prophylaxis (PrEP) is a crucial HIV prevention strategy, yet adherence remains a significant challenge. Understanding the factors that influence adherence is essential to optimizing PrEP effectiveness. This study investigated the factors associated with client PrEP adherence using a cross-sectional survey with a sample size of 200 clients. The target population were the clients receiving PrEP services at healthcare facilities in Uganda. Multivariate logistic regression analysis was used to identify significant predictors of adherence. The findings indicate that age, gender employment status, education level, duration of PrEP, discussion of PrEP with family or friends, number of sexual partners, stigma, mental health concerns and access to PrEP services had a significant association on PrEP adherence, while reduced worry of contracting HIV and side effects had no significant association on PrEP adherence. These results highlight the importance of addressing specific factors to enhance PrEP adherence. The study’s results provide valuable insights into the complex factors influencing PrEP adherence. This study contributes to the growing body of evidence on PrEP adherence and provides insights for healthcare providers, policymakers, and researchers to develop targeted interventions that improve adherence and maximize the effectiveness of PrEP in preventing HIV transmission. By understanding the determinants that influence adherence, we can work towards optimizing PrEP programs and reducing the burden of HIV transmission in high-risk populations.