Prevalance of ESBL and carbapenemase-producing klebsiella pneumoniae from clinical isolates at Makerere University Medical Microbiology Labaratory.
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Date
2022-10-04Author
Ivundya, Samuel
Kakeeto, James
Ssesanga, Godfrey
Wokorach, Gabriel
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Show full item recordAbstract
Klebsiella pneumoniae is known normal flora of the gastrointestinal tract of humans. It belongs
to the family Enterobacteriaceae and is associated with pneumonia in immunocompromised
hosts. Other disease caused by K.pneumoniae include urinary tract infections, abdominal
infections and bloodstream infections.
Antibiotic resistance associated with extended-spectrum beta-lactamases (ESBLs) and
carbapenemase-producing Enterobacteriaceae is profound in healthcare settings. This is
attributed to the presence of bacteria like K. pneumoniae with hospitals, as nosocomials. These
bacteria are harbored by healthcare workers, support staff and patients, but are also present on
commonly touched surfaces such tap handles, door handles, patient beds and the floors.
Studies done elsewhere show and increased prevalence of ESBL and Carbapenemase- klebsiella
pneumonia in healthcare settings. However, information regarding the prevalence of such
resistant bacteria is lacking in our setting. Therefore, our study aimed at determining the
prevalence of ESBL and carbapenemase producing K. pneumoniae among clinical isolates at the
Medical Microbiology laboratory.
Our study was a retrospective study to collect data in the Makerere medical microbiology
laboratory of the confirmed Klebsiella pneumoniae that were ESBL and Carbapenemase
producing. We used a quantitative tool to collect data of 106 samples of klebsiella pneumoniae
identified isolates.
We found an increased frequency (83.96%) of Klebsiella pneumonia ESBL producing isolates as
compared to those that are carbapenemase producing (7.55%).This proportion was higher than
that found in earlier studies by Kateregga et al., 2015 and Kung et al., 2015, at 62% and 13.5%
respectively.
Therefore, our study revealed a higher prevalence of ESBL producing Klebsiella pneumonia
within the same setting.