School of Biosecurity, Biotechnolgy and Laboratory Sciences (SBLS) Collection
Recent Submissions
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Structural analysis of the interaction of embB protein mutations of Mycobacterium tuberculosis with ethambutol and their effect on the interaction
(Makerere University, 2024)Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a global health challenge exacerbated by the emergence of drug-resistant strains. Ethambutol is a critical first-line anti-TB drug targeting the embB protein, ... -
Prevalence and co-occurrence of fecal occult blood and helicobacter pylori inn patients presenting with dyspeptic symptoms at Makerere University Hospital
(Makerere University, 2024-06)Helicobacter pylori has been associated with the risk of a wide spectrum of clinical outcomes. Fecal occult blood is hidden blood that cannot be seen with the naked eyes found in stool. Positive fecal occult blood test is ... -
Structural analysis of pathogenic proteins of B. anthracis and their interaction with human proteins
(Makerere University, 2024-06)Anthrax pathogenic proteins, including Protective Antigen (PA), Lethal Factor (LF), and Edema Factor (EF), are central to the virulence of Bacillus anthracis, presenting a significant threat to public health and national ... -
Evaluation of anti inflammatory properties and toxicity of aqueous and ethanolic extracts of Plectranthus cyaneus in Swiss albino mice
(Makerere University, 2024)Traditional medicinal plants have been used over the years for the treatment of health problems including acute and chronic inflammation in management of inflammation associated diseases. This study was aimed at evaluating ... -
Viability of indigenous probiotic bacteria of swine origin under room temperature
(Makerere University, 2024-06)Probiotics are live useful microorganisms which when administered in adequate amounts confer a health benefit on the host both humans and animals. The demand of probiotics as a bio-control therapy is rapidly increasing in ... -
Evaluation of the use of propolis as a replacement for synthetic antibiotics in boar semen extenders
(Makerere university, 2024-06)Antibiotics are of great importance in semen extenders to ensure long shelf life of spermatozoa and control bacterial contamination. These bacteria compete with the sperms for nutrients and produce toxic substances that ... -
In silico prediction of vaccine candidate b cell epitopes of plasmodium falciparum circumsporozoite protein for the control of malaria
(Makerere University, 2024-04)Malaria remains one of the most infectious diseases worldwide causing an estimate of 249 million cases and 608,000 deaths annually predominantly among children under five years of age. Malaria is caused by plasmodium ... -
In-silico assessment of candidate B-cell epitopes and chimeric proteins from glycoproteins (B, D, C, E, I) for management of herpes simplex virus- 2 infections
(Makerere University, 2024-06)The HSV-2, a significant global health concern, demands innovative control methods. This project employed advanced in-silico techniques to analyze and design chimeric proteins utilizing selected glycoproteins (gD, gB, gC, ... -
Assessment of levels of heavy metals in spring water in Nsooba/Mulago 3, Kampala District, Uganda
(Makerere University, 2024-10)Due to the rapid urbanization that has occurred in Nsooba-mulago III over the last few decades, metals have been continuously emitted into the urban environment and now pose a serious threat to human health. Indeed, there ... -
Blood stream infections and antimicrobial susceptibility patterns in critical care patients at Nakasero hospital
(Makerere University, 2024)Blood stream infection contributes to mortality and morbidity among inpatients. Antimicrobial resistance further complicates sepsis management across all settings, particularly neonates and patients in critical care units ... -
Evaluation of the anti-diabetic property and acute oral toxicity of momordica charantia ethanol extract in wistar albino rats
(Makerere University, 2024-06)Diabetes mellitus is a chronic disorder of carbohydrate metabolism characterized by hyperglycemia and glycosuria caused by absolute insulin deficiency or insufficiency. For centuries, traditional medicinal plants have been ... -
Exploring lytic bacteriophages as alternatives for combating multi drug-resistant Acinetobacter baumannii
(Makerere University, 2024)Multi-Drug Resistant (MDR) Acinetobacter baumannii (A. baumannii) is a serious threat to human health worldwide typically due to its resistance to a wide variety of major classes of antibiotics. It is associated with ... -
Characterization of the lytic activity of bacteriophages against Shigella dysenteriae
(Makerere University, 2024)Introduction: Shigella dysenteriae is endemic in most regions of most developing countries including Uganda. Emergence of increased levels of multi-drug resistant Shigella dysenteriae strains has become worrisome in the ... -
Effects of thawing times and temperatures on frozen semen of Boran bulls in Uganda
(Makerere University, 2024)Artificial insemination (AI) is the key technology in livestock production and is critically important for the maintenance of genetic diversity (Niemann & Wrenzycki, 2018). However in Uganda AI has been adopted less than ... -
Effect of animal level factors on the semen quality in dairy breeds at National Animal Genetic Resources Center and Databank
(Makerere University, 2024)Dairy industry contributes greatly to the GDP and to the Global economy with a population of more than 270 million producing 700 tons of milk but due to land scarcity as a result of increased population , keeping of bulls ... -
Investigating the effects of exposure to commonly used insecticides and mosquito repellents on Murine lungs, liver and kidney tissues
(Makerere University, 2024)Cypermethrin, a synthetic pyrethroid, has broad- spectrum use in agriculture, domestic and veterinary applications due to its high bioefficacy, enhanced stability and considerably low mammalian toxicity. The objective of ... -
Determination of antimicrobial resistance profiles of Edwardsiella species isolated from fish sold in markets around Kampala
(Makerere University, 2024-08)Edwardsiella tarda, causes zoonoses in humans and is vectored by fish, hence a serious threat to aquaculture sector globally. However, there is limited information on its antibiotic susceptibility in fish sold on Ugandan ... -
Characterization of Cefotaxime Resistant Klebsiella Pneumoniae (CRKP) isolated from the environment of selected chicken farms in Wakiso District, Uganda
(Makerere University, 2024)Poultry can harbor antibiotic-resistant bacteria that pose a threat to human health through contaminated food or direct contact. This study investigated the characteristics of cefotaximeresistant Klebsiella pneumoniae ... -
In-silico identification of candidate B cell epitopes and evaluation of chimeric proteins derived from FIMH,WZA and HMA proteins for the control of Uropathogenic Escherichia coli infections.
(Makerere University, 2024)Uropathogenic Escherichia coli (UPEC) are common pathogens in urinary tract infections (UTIs), which show resistance to antibiotics; necessitating a vaccine to reduce susceptibility to these infections. In this study, ... -
Immunoinformatics aided design and evaluation of chimeric proteins with B cell epitopes from E2, E5, E6 and E7 proteins of Human Papillomavirus – 16
(Makerere University, 2024)Human papillomavirus (HPV) infection, particularly HPV-16, is a significant global health concern due to its association with various cancers including cervical cancer. Despite existing prophylactic vaccines, there is a ...
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